SHI supported the establishment and early operationalisation of the African Medicines Agency (AMA) and its emerging continental laboratory network, in partnership with AUDA-NEPAD, the African Union Commission, and national regulators. The work focused on translating political mandate into functional readiness, including Governing Board operations, secretariat systems, and the development of a reliance-based continental laboratory network.

This contributed to the progression of harmonised regulatory mechanisms from pilot platforms to operational systems, including the first continental listing of medical products following joint evaluation. SHI supported coordination and ensured disciplined execution, while leadership, decision-making, and ownership remained with AMA and African regulators.